A NONIDENTIFIABILITY ASPECT OF THE 2-STAGE MODEL OF CARCINOGENESIS

Authors
HANIN LG YAKOVLEV AY
Citation
Lg. Hanin et Ay. Yakovlev, A NONIDENTIFIABILITY ASPECT OF THE 2-STAGE MODEL OF CARCINOGENESIS, Risk analysis, 16(5), 1996, pp. 711-715
Citations number
10
Categorie Soggetti
Social Sciences, Mathematical Methods
Journal title
Risk analysis → ACNP
ISSN journal
02724332
Volume
16
Issue
5
Year of publication
1996
Pages
711 - 715
Database
ISI
SICI code
0272-4332(1996)16:5<711:ANAOT2>2.0.ZU;2-3
Abstract
This paper discusses identifiability of the two-stage birth-death-muta tion model of carcinogenesis. It is shown that the homogeneous version of the model is nonidentifiable; the same is all the more evident for its nonhomogeneous versions. This result implies that the model param eters cannot be uniquely estimated from time-to-tumor observations.