INTERFERONS AND THE TUMOR-CELL

Optimal use of interferons (IFNs) for the treatment of tumor disease r equires experimental work in order to precisely define IFN actions. We have pointed out three modes of such actions relevant for the antitum or efficacy exerted by IFNs: effects on apoptosis, effects on genes in volved in malignant transformation and effects on angiogenesis. These are but three selected areas forming a basis for the development of op timal IFN therapy. Further experimental work, undertaken in these and additional IFN areas, is mandatory for the most effective clinical use of IFNs for the treatment of tumor disease.