REVERSIBLE BINDING OF ANTHRACYCLINE ANTIBIOTICS TO ERYTHROCYTES TREATED WITH GLUTARALDEHYDE

Authors
ATAULLAKHANOV FI KULIKOVA EV VITVITSKY VM
Citation
Fi. Ataullakhanov et al., REVERSIBLE BINDING OF ANTHRACYCLINE ANTIBIOTICS TO ERYTHROCYTES TREATED WITH GLUTARALDEHYDE, Biotechnology and applied biochemistry, 24, 1996, pp. 241-244
Citations number
20
Categorie Soggetti
Biology,"Biothechnology & Applied Migrobiology
Journal title
Biotechnology and applied biochemistry → ACNP
ISSN journal
08854513
Volume
24
Year of publication
1996
Part
3
Pages
241 - 244
Database
ISI
SICI code
0885-4513(1996)24:<241:RBOAAT>2.0.ZU;2-A
Abstract
Human erythrocytes treated with glutaraldehyde can take up anthracycli ne antibiotics (daunorubicin and doxorubicin) from the incubation medi um and do so faster than untreated cells. The antibiotics are readily released when the suspending medium is replaced with an antibiotic-fre e one. Our findings provide evidence that glutaraldehyde-treated eryth rocytes remain capable of reversible binding of anthracycline antibiot ics.