Background: Most published reviews and audits of blood and blood compo
nent transfusion have focused on the issue of overtransfusion and on t
he inappropriate use of red cell components. There is growing concern
that efforts to curb unnecessary transfusions may result in a trend to
ward undertransfusion of patients. There is little published informati
on that addresses this issue or the magnitude of this practice. Study
Design and Methods: Undertransfusion was evaluated by examining the tr
ansfusion records from a 3-month period for 55 patients who met the st
udy criteria of having either a hemoglobin level <7 g per dL or a plat
elet count of <10 x 10(9) per L. If the identified patient did not rec
eive a transfusion within 24 hours of the reported hemoglobin level or
platelet count, the medical record was reviewed by a resident physici
an. Results: A total of 213 individual hemoglobin levels and platelet
counts, representing the 55 patients, met our transfusion criteria. Al
l except 8 of the identified patients received red cells and/or platel
et transfusions. Reasons for not transfusing red cells included the pa
tient's response to nutritional support and iron supplementation, refu
sal of blood, and noncompliance. Reasons for not transfusing platelets
included falsely low platelet count because of platelet clumping in v
itro, contraindication based on clinical diagnosis (e.g., immune throm
bocytopenic purpura), and the patient's death before transfusion. Conc
lusion: Red cell and platelet transfusions were appropriately ordered
for all patients who met the transfusion criteria. Undertransfusion Is
not a problem at this institution according to the criteria establish
ed. It is recommended that other institutions expand their blood utili
zation audits to include investigation for evidence of undertransfusio
n. Further research regarding the issue of undertransfusion is warrant
ed and could be expanded to include other components.