PALLADIUM-CATALYZED CROSS-COUPLING REACTIONS OF ARYLMETAL COMPOUNDS WITH BETA-SUBSTITUTCD ALPHA-IODOENONES AND A CYCLOHEXYL TRIFLATE

Authors
BOSSE F TUNOORI AR NIESTROJ AJ GRONWALD O MAIER ME
Citation
F. Bosse et al., PALLADIUM-CATALYZED CROSS-COUPLING REACTIONS OF ARYLMETAL COMPOUNDS WITH BETA-SUBSTITUTCD ALPHA-IODOENONES AND A CYCLOHEXYL TRIFLATE, Tetrahedron, 52(28), 1996, pp. 9485-9498
Citations number
52
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
52
Issue
28
Year of publication
1996
Pages
9485 - 9498
Database
ISI
SICI code
0040-4020(1996)52:28<9485:PCROAC>2.0.ZU;2-A
Abstract
Electron-rich arylstannanes were found to couple with alpha-iodoenones in the presence of Pd-2(dba)(3) CHCl3, a weak-coordinating ligand [As Ph(3) or Pd(o-tol)(3)] and CuI (0.75-1.0 equiv) to give sterically hin dered alpha-arylcyclohexenones 15-20. In addition, compounds 19, 22 an d 23 were prepared by Suzuki coupling reactions of the cyclohexyl deri vatives 7c,f and 11, respectively, with the arylboronic acid 21. Copyr ight (C) 1996 Elsevier Science Ltd