VALIDATION OF A RELEASE DIFFUSION CELL FOR TOPICAL DOSAGE FORMS

The methodology followed to choose the agitation speed and posterior v alidation of a new design of diffusion cell, used in studies of in-vit ro release of naproxen in the classical topical dosage forms is descri bed. It was found that the methodology is repeatable, reproducible and robust for the chosen speed (600 rev./min) providing that the test te mperature is carefully controlled.