SKELETAL RESPONSE TO IMMOBILIZATION IN PAGETS-DISEASE OF BONE - A CASE-REPORT

The authors discuss a case of Paget's disease of the forearm in which the Pagetic radius and non-Pagetic ulna responded differently to immob ilization. The high turnover state of Pagetic hone is more sensitive t o physical unloading than normal bone, and thus more rapidly develops osteopenia of immobilization, The different responses to immobilizatio n between Pagetic bone and site controlled normal bone illustrate how physical and metabolic factors interact at a skeletal site to regulate bone remodeling and bone mass.