OCCURRENCE OF NITRO AND NON-NITRO BENZENOID MUSK COMPOUNDS IN HUMAN ADIPOSE-TISSUE

Nitro benzenoid musk compounds (Musk tibetene [CAS no. 145-39-1], Musk ambrette [83-66-9], Musk moskene [116-66-5], Musk ketone [81-14-1] an d Musk xylene [81-15-2]) and non-nitro benzenoid musks (Celestolide (R ) [13171-00-1], Galaxolide (R) [1222-05-5]) and Fixolide (R) [1506-02- 1] [21445-77-7]) were analysed in 15 human adipose tissue samples from Switzerland by gas chromatography/high resolution mass spectrometry. The levels of Musk xylene and Galaxolide ranged up to 288 ng/g lipids and 171 ng/g lipids, respectively. The concentrations of non-nitro ben zenoid musks found in human adipose tissue raise concern since very fe w toxicological data are available. Copyright (C) 1996 Elsevier Scienc e Ltd