RELATIONSHIP BETWEEN IMMUNOINFLAMMATORY PROTEINS CONTAINING SIALIC-ACID AND LOW-DENSITY-LIPOPROTEIN SERUM CONCENTRATIONS

The aim of this study was to investigate the relationship between sial oglycoproteins and the lipoprotein profile in a group of children with different levels of low-density lipoprotein cholesterol. We have stud ied 177 children of 132 families who were sent to our Pediatric Lipid Research Clinic because of serum cholesterol concentrations higher tha n 5.17 mmol/l. At the time of diagnosis, we analyzed the serum lipopro tein profile and the sialoglycoproteins: alpha(1)-antitrypsin, acid al pha(1)-glycoprotein, haptoglobin, alpha(2)-macroglobulin, transferrin, IgA, IgG, IgM, complement C3 component and ceruloplasmin. At 7.0 to 1 0.9 years, alpha(1)-glycoprotein serum concentrations were higher in t he high risk group than in the moderate risk group (P < 0.05). At 2.0 to 6.9 years, IgA and IgM serum concentrations were higher in the mode rate risk group than in the low risk group (P < 0.05 and P < 0.01, res pectively), and IgG and IgM serum concentrations were also higher in t he high risk group than in the low risk group (P < 0.05). Our results seems to reflect a general reaction to injury or inflammation which co uld be associated with the atherosclerotic process.