ON THE ASSOCIATION BETWEEN CANINE MALIGNANT-LYMPHOMA AND OPPORTUNITY FOR EXPOSURE TO 2,4-DICHLOROPHENOXYACETIC ACID

In response to criticisms raised regarding a case-control study of can ine malignant lymphoma, the results of several ancillary analyses are reported. The case-control study demonstrated a significant associatio n between risk for canine malignant lymphoma and the opportunity for e xposure to 2,4-dichlorophenoxyacetic acid herbicides. It is demonstrat ed that risk estimates do not vary by type of control group (i.e., tum or control or nontumor control group), by method of response (i.e., se lf-administered or telephone interview), or by geographic area. Questi ons related to the potential for referral bias, supposed inconsistenci es in subject responses regarding frequency of herbicide use, and ambi guities regarding exposure classification are also examined. (C) 1995 Academic Press, Inc.