ANTHELMINTIC ACTIVITY OF 6,7-DIARYL-PTERIDINES

Authors
OCHOA C RODRIGUEZ J GARCIA MLL MARTINEZ AR MARTINEZ MM
Citation
C. Ochoa et al., ANTHELMINTIC ACTIVITY OF 6,7-DIARYL-PTERIDINES, Arzneimittel-Forschung, 46(6), 1996, pp. 643-648
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Arzneimittel-Forschung → ACNP
ISSN journal
00044172
Volume
46
Issue
6
Year of publication
1996
Pages
643 - 648
Database
ISI
SICI code
0004-4172(1996)46:6<643:AAO6>2.0.ZU;2-K
Abstract
In a search for new anthelmintic compounds, some 6,7-diaryl-pteridines were synthesized from the corresponding diaminopyrimidines and aromat ic aldehydes. Their anthelmintic activity was tested in vitro against Caenorhabditis elegans and Heligmosomoides polygyrus and in vivo again st Trichinella spiralis. Structure-activity relationships are discusse d.