IN-VITRO EVALUATION OF 6-AMINO-5,6-DIHYDR O-4H-CYCLOPENTA (C) THIOPHENE-4-ONES ANTIFUNGAL ACTIVITY ON MICROSPORUM-CANIS

Propose. The interest of the present study was to test the activity ag ainst Microsporum canis of fifteen produces from the chemistry family of 6-amino-5,6-dihydro-4H-cyclopenta (C) thiophen-4-ones. Results. Onl y two produces present an interest. The minimal inhibitory concentrati ons (MIC) are evaluate fur each produce. The MLC of product MR 16844 i s of 0.061 mu g.ml(-1) in liquid media and of 9.76 mu g.ml(-1) in soli d media; whereas MIC's salt MR 19220 is identic in both media, 19.53 m u g.ml(-1). The results evaluated antifungal activity are compared wit h griseofulvin as reference molecule.