KINECTIN DISTRIBUTION IN CHICKEN NERVOUS-SYSTEM

Kinectin, a major kinesin receptor on endoplasmic reticulum, was visua lized with anti-kinectin monoclonal antibodies (mAbs) in the adult chi cken nervous system in comparison with kinesin immunostaining. Anti-ki nectin mAbs punctately stained cell bodies and proximal dendrites of m otor neurons in spinal cords. Axons of motor neurons were not stained with anti-kinectin mAbs, but stained heavily with anti-kinesin mAbs. T his suggest that the kinesin receptor responsible for kinesin-driven a nterograde fast axonal transport is different from kinectin. Anti-kine ctin mAbs strongly stained neuronal cell bodies in spinal ganglion, nu clei in brainstem, cerebellar nuclei, striatum and cerebral cortex. Sm all neurons in cerebellar cortex and optic lobe showed relatively weak reaction, suggesting that the amount of kinectin correlates with the size of neuronal cell bodies.