A SELECTIVE PROCEDURE FOR ALPHA-ALKENYLATION OF ENONES INVOLVING PD-CATALYZED ALKENYL-ALKENYL COUPLING AND ITS APPLICATION TO A CONVERGENT AND EFFICIENT SYNTHESIS OF NAKIENONE-B

Authors
POUR M NEGISHI E
Citation
M. Pour et E. Negishi, A SELECTIVE PROCEDURE FOR ALPHA-ALKENYLATION OF ENONES INVOLVING PD-CATALYZED ALKENYL-ALKENYL COUPLING AND ITS APPLICATION TO A CONVERGENT AND EFFICIENT SYNTHESIS OF NAKIENONE-B, Tetrahedron letters, 37(27), 1996, pp. 4679-4682
Citations number
31
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
27
Year of publication
1996
Pages
4679 - 4682
Database
ISI
SICI code
0040-4039(1996)37:27<4679:ASPFAO>2.0.ZU;2-B
Abstract
A convergent and efficient synthesis of a marine natural product, naki enone B (1), was achieved using a new protocol for a-alkenylation of e nones involving Pd-catalyzed coupling of alkenylzincs with alkenyl iod ides. This protocol features (i) avoidance of acidic conditions and (i i) flexibility in charge affinity pattern with respect to the two aken yl groups to be coupled. Copyright (C) 1996 Elsevier Science Ltd