A HIGH-YIELD SEMISYNTHETIC APPROACH TO 2'-EPI-TAXOL

Authors
CABRI W CURINI M MARCOTULLIO MC ROSATI O
Citation
W. Cabri et al., A HIGH-YIELD SEMISYNTHETIC APPROACH TO 2'-EPI-TAXOL, Tetrahedron letters, 37(27), 1996, pp. 4785-4786
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
27
Year of publication
1996
Pages
4785 - 4786
Database
ISI
SICI code
0040-4039(1996)37:27<4785:AHSAT2>2.0.ZU;2-T
Abstract
A new 2-steps synthesis of 2'-epi-Taxol starting from natural Taxol(R) is described. The approach is centred on the formation of oxazoline o n the side chain with concomitant inversion of the C-2' followed by ac id hydrolysis. Copyright (C) 1996 Elsevier Science Ltd