MUCOSAL PERMEABILITY OF ILEAL AND COLONIC RESERVOIRS FOR URINE

Objectives To evaluate the intestinal mucosal permeability in continen t reservoirs for urine. Patients and methods The mucosal permeability in continent urinary reservoirs, constructed either from an ileal or a colonic segment (six patients each), was assessed by analysing serial samples of plasma, after instilling the reservoir with Cr-51-ethylene diaminetetra-acetic acid (Cr-51-EDTA), and serum, after instillation with polyethylene glycol (PEG 400). Results There was no or negligible permeation of Cr-51-EDTA and PEG 400 in either type of reservoir, as there was no significant increase of the markers in plasma and serum, respectively. Conclusion The intestinal barrier to medium-sized hydrop hilic molecules seems intact in continent urinary reservoirs, The lack of significant permeation of Cr-51-EDTA confirms the usefulness of a single injection of Cr-51-EDTA for the determination of glomerular fil tration rate in patients with intestinal urinary diversion.