KINDLING OF RAT EPILEPSY BY INTRACEREBROVENTRICULAR INJECTION OF NORFLOXACIN AND ULTRASTRUCTURAL-CHANGES OF BRAIN

AIM: To study the toxic effects of norfloxacin (Nor) on EEG and ultras tructure of the brain. METHODS: EEG was recorded in the sensorimotor a rea of. rat colter after Nor 150 and 300 mu g . kg(-1) were Injected i nto the right ventricle of the brain. RESULTS: Spike waves occurred, f irst at the ipsilateral side and then bilaterally. The seizure spike a ppeared at 168 +/- 129, 51 +/- 35 s, and 276 +/- 138, 118 +/- 65 s in the right and left cerebral cortices in 150 and 300 mu g . kg(-1) grou ps, respectively. The wave forms were variable, the wave amplitude and frequency increased gradually, accompanied with limb twitching. Neuro n degeneration was seen in both cerebral hemispheres, hippocampus, and cerebellum 120 min after the icy of Nor 300 mu g . kg(-1): myeloid de generation of Golgi complex, rough endoplasmic reticulum, and neuropil s; swelling of cytoplasm; dissolution of nuclears and chromatin; necro sis of gliocytes and the appearance of changes in both the light and d ark neurons, especially the dark ones. CONCLUSION: Rat brain was widel y damaged after the kindling by Nor.