INCREASED MONOCYTE CYTOKINE PRODUCTION IN ASSOCIATION WITH SYSTEMIC COMPLICATIONS IN ACUTE-PANCREATITIS

Citation
Cj. Mckay et al., INCREASED MONOCYTE CYTOKINE PRODUCTION IN ASSOCIATION WITH SYSTEMIC COMPLICATIONS IN ACUTE-PANCREATITIS, British Journal of Surgery, 83(7), 1996, pp. 919-923
Citations number
34
Categorie Soggetti
Surgery
Journal title
ISSN journal
00071323
Volume
83
Issue
7
Year of publication
1996
Pages
919 - 923
Database
ISI
SICI code
0007-1323(1996)83:7<919:IMCPIA>2.0.ZU;2-X
Abstract
Tumour necrosis factor (TNF) alpha, interleukin (IL) 1 beta, IL-6 and IL-8 are thought to play a central role in the pathophysiology of seps is but their role in acute pancreatitis is unknown. In the present stu dy, monocytes were isolated from the peripheral blood of 26 patients w ith moderate or severe acute pancreatitis without biliary sepsis. Secr etion of these cytokines in vitro was measured at intervals during the first week of illness. Sixteen patients developed systemic complicati ons. Peak TNF-alpha secretion was significantly higher in patients who developed systemic complications (median (interquartile range (i.q.r. )) 18.5 (5.5-28.5) ng/ml) than in those with an uncomplicated course ( 3.7 (2.3-6.4) ng/ml, P<0.01). Similarly, peak IL-6 and peak IL-8 secre tion were significantly higher in the complicated group (IL-6: complic ated median (i.q.r.) 48.9 (12.1-71.0) ng/ml, uncomplicated 16.3 (14.2- 37.9) ng/ml, P<0.05; IL-8: complicated 748 (643-901) ng/ml, uncomplica ted 608 (496-749) ng/ml), P<0.05). No significant difference in peak I L-1 beta secretion was observed between the two groups. Systemic compl ications of acute pancreatitis are associated with a significant incre ase in monocyte secretion of TNF-alpha, IL-6 and IL-8 suggesting that, as in sepsis, these cytokines play a central role in the pathophysiol ogy of the disease.