G-CSF AS AN ADJUNCT TO ANTIBIOTIC-TREATME NT IN PATIENTS WITH LUPUS-ASSOCIATED NEUTROPENIA AND INFECTION

Authors
SCHWAB UM HARTEN P ZEUNER RA KULPER M EULER HH
Citation
Um. Schwab et al., G-CSF AS AN ADJUNCT TO ANTIBIOTIC-TREATME NT IN PATIENTS WITH LUPUS-ASSOCIATED NEUTROPENIA AND INFECTION, Zeitschrift fur Rheumatologie, 55(3), 1996, pp. 174-179
Citations number
37
Categorie Soggetti
Rheumatology
Journal title
Zeitschrift fur Rheumatologie → ACNP
ISSN journal
03401855
Volume
55
Issue
3
Year of publication
1996
Pages
174 - 179
Database
ISI
SICI code
0340-1855(1996)55:3<174:GAAATA>2.0.ZU;2-V
Abstract
Nine patients with SLE-associated neutropenia and infections received 48 Mio U G-CSF per day sc. for 2-17 days as an adjunct to antibiotic t reatment. Granulopoiesis was normal or hyperplastic in all cases. The mean granulocyte count increased within 2 days from 1.4 per nl to 11.4 per nl. Side-effects were exacerbating CNS symptoms in two patients a nd a case of leukocytoclastic vasculitis. G-CSF induced constantly a r apid and distinct increase of neutrophil granulocytes in lupus-associa ted neutropenia patients with normo- or hyperplastic granulopoiesis.