Many vitelliform macular diseases have been described through the year
s. Some arguments still exist about the appropriate terminology, the c
lassification criteria and the etiopathogenesis. The alterations of th
e retinal pigment epithelium, the lipofuscin storage and the role of t
he choriocapillaris are being investigated. The aim of our study was t
o describe indocyanine angiographic features in Best's disease and pat
tern distrophies. Twenty-one eyes of 14 patients underwent indocyanine
and fluorescein angiography. The indocyanine angiogram showed hypoflu
orescent and hyperfluorescent areas. The possible etiopathogenesis of
the lesions includes a role of the retinal pigment epithelium.