ANTIMICROBIAL RESISTANCE IN FECAL FLORA - LONGITUDINAL COMMUNITY-BASED SURVEILLANCE OF CHILDREN FROM URBAN MEXICO

We assessed the colonization patterns, over time, of three sentinel dr ug-resistant enteric bacterial genera in samples from a cohort of 20 h ealthy small children in a periurban community in Mexico, The children were monitored during a 13-week period by means of weekly home visits and examinations of stool collections, These specimens were tested fo r the presence of Escherichia coli, Klebsiella species, and Shigella s pecies resistant to one or more of seven antimicrobial agents, Ninety, 77, and 62% of the stool specimens had E. coli isolates resistant to ampicillin, trimethoprim, and tetracycline, respectively, Simultaneous resistance to more than one antibiotic by an E. coli isolate was obse rved in 88.5% of stool samples, Persistent fecal shedding of ampicilli n-, trimethoprim-, and tetracydine-resistant E. coli occurred during t he study period in the majority of children, We detected colonization by E. coli resistant to chloramphenicol, gentamicin, nitrofurantoin, o r norfloxacin, as well as by Klebsiella species and Shigella species r esistant to one of these antibiotics, in fewer children and for shorte r periods, These data suggest the common and persistent intestinal she dding of multidrug-resistant E. coli strains by small healthy children .