ENHANCED OXIDATIVE KILLING OF AZOLE-RESISTANT CANDIDA-GLABRATA STRAINS WITH ERG11 DELETION

Authors
KAN VL GEBER A BENNETT JE
Citation
Vl. Kan et al., ENHANCED OXIDATIVE KILLING OF AZOLE-RESISTANT CANDIDA-GLABRATA STRAINS WITH ERG11 DELETION, Antimicrobial agents and chemotherapy, 40(7), 1996, pp. 1717-1719
Citations number
24
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
40
Issue
7
Year of publication
1996
Pages
1717 - 1719
Database
ISI
SICI code
0066-4804(1996)40:7<1717:EOKOAC>2.0.ZU;2-I
Abstract
The susceptibility of genetically defined Candida glabrata strains to killing by H2O2 and neutrophils was assessed. Fluconazole susceptible L5L and L5D strains demonstrated survival rates higher than those of t wo fluconazole-resistant strains lacking the ERG11 gene coding for 14 alpha-demethylase. Fluconazole resistance can occur by mechanisms whic h increase fungal susceptibility to oxidative killing by H2O2 and neut rophils.