J. Tamaoki et al., EFFECTS OF ROXITHROMYCIN AND ERYTHROMYCIN ON INTERLEUKIN 8-INDUCED NEUTROPHIL RECRUITMENT AND GOBLET CELL SECRETION IN GUINEA-PIG TRACHEAS, Antimicrobial agents and chemotherapy, 40(7), 1996, pp. 1726-1728
Inhaled interleukin 8 caused an increase in goblet cell secretion in g
uinea pig tracheas, which was accompanied by mucosal infiltration of n
eutrophils, These responses were inhibited by pretreatment with roxith
romycin or erythromycin in a dose-dependent fashion, Macrolides may th
us be of value in protecting against neutrophil-associated airway hype
rsecretion.