T. Zimmermann et al., RESULTS OF ELECTIVE LYMPH-NODE DISSECTION IN MALIGNANT-MELANOMA OF THE TRUNK, Zentralblatt fur Chirurgie, 121(6), 1996, pp. 478-482
In our department, between 1979 and 1994, 253 patients, thereof 171 ma
le, 83 female with the average age of 48.2 years underwent surgery bec
ause of stage 1 (T2) to stage 3 melanoma that was located on the trunc
. Our retrospective analysis was based on those 211 patients who had b
een followed up by the department of dermatology in our medical center
. It was the aim of our study-apart from determining the long-term-pro
gnosis- to find out the number of patients in whom a curative resectio
n could be only achieved by elective lymph node dissection. The 5-year
survival rate amounted to 79 % for all patients. For patients sufferi
ng from stage 1-disease (T2) it was 93 %, for those with stage 2-disea
se 89 %, and in case of stage 3-disease 49 % respectively. After ELND
had been performed, no lymph node metastases were found in patients (0
/22) suffering from a T2-tumor. In case of T3-tumors, in 13 % (11/82)
and in case of T4-tumors in 30 % (13/ 43) lymph node metastases were f
ound. However, only 5 out of 11 patients, with the established diagnos
is of a T3-tumor in whom positive lymph-nodes had been found by ELND,
and merely 6 out of the 13 patients with a T4-tumor, are still alive a
fter a mean follow-up period of 74 months. We conclude that ELND is no
t indicated in patients with T2-melanoma. In case of T3- and T4-melano
ma, some doubts exist whether patients really benefit from this surgic
al procedure. Randomized prospective studies are necessary to clarify
the importance of electiv lymph node dissection.