INHIBITION OF ALDOSE REDUCTASE BY DIHYDROFLAVONOLS IN ENGELHARDTIA-CHRYSOLEPIS AND EFFECTS ON OTHER ENZYMES

Authors
HARAGUCHI H OHMI I MASUDA H TAMURA Y MIZUTANI K TANAKA O CHOU WH
Citation
H. Haraguchi et al., INHIBITION OF ALDOSE REDUCTASE BY DIHYDROFLAVONOLS IN ENGELHARDTIA-CHRYSOLEPIS AND EFFECTS ON OTHER ENZYMES, Experientia, 52(6), 1996, pp. 564-567
Citations number
30
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Experientia → ACNP
ISSN journal
00144754
Volume
52
Issue
6
Year of publication
1996
Pages
564 - 567
Database
ISI
SICI code
0014-4754(1996)52:6<564:IOARBD>2.0.ZU;2-B
Abstract
Astilbin and neoastilbin, dihydroflavonol rhamnosides from Engelhardti a chrysolepis, showed potent inhibition of lens aldose reductase. Kine tic analysis showed astilbin exhibited uncompetitive inhibition agains t both dl-glyceraldehyde and NADPH. These taxifolin glycosides were se lective inhibitors of aldose reductase with no inhibition of NADH oxid ase.