CYCLIC-AMP INHIBITS EXPRESSION OF D-TYPE CYCLINS AND CDK4 AND INDUCESP27(KIP1) IN G-CSF-TREATED NFS-60 CELLS

Authors
WARD AC CSAR XF HOFFMANN BW HAMILTON JA
Citation
Ac. Ward et al., CYCLIC-AMP INHIBITS EXPRESSION OF D-TYPE CYCLINS AND CDK4 AND INDUCESP27(KIP1) IN G-CSF-TREATED NFS-60 CELLS, Biochemical and biophysical research communications, 224(1), 1996, pp. 10-16
Citations number
41
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
224
Issue
1
Year of publication
1996
Pages
10 - 16
Database
ISI
SICI code
0006-291X(1996)224:1<10:CIEODC>2.0.ZU;2-6
Abstract
The addition of cAMP inhibits G-CSF-mediated proliferation and suppres ses pRB phosphorylation in NFS-60 cells. We show that the latter could be attributed to different effects of cAMP in these cells: (i) down-r egulation of the levels of cyclins D2 and D3, and cdk4, and (ii) induc tion of the p27(Kipl) inhibitor of cdk4. (C) 1996 Academic Press, Inc.