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The addition of cAMP inhibits G-CSF-mediated proliferation and suppres
ses pRB phosphorylation in NFS-60 cells. We show that the latter could
be attributed to different effects of cAMP in these cells: (i) down-r
egulation of the levels of cyclins D2 and D3, and cdk4, and (ii) induc
tion of the p27(Kipl) inhibitor of cdk4. (C) 1996 Academic Press, Inc.