INTERACTION OF RGD LIPOSOMES WITH PLATELETS

Authors
Citation
T. Nishiya et S. Sloan, INTERACTION OF RGD LIPOSOMES WITH PLATELETS, Biochemical and biophysical research communications, 224(1), 1996, pp. 242-245
Citations number
17
Categorie Soggetti
Biology,Biophysics
ISSN journal
0006291X
Volume
224
Issue
1
Year of publication
1996
Pages
242 - 245
Database
ISI
SICI code
0006-291X(1996)224:1<242:IORLWP>2.0.ZU;2-F
Abstract
The interactions of platelets and liposomes with the tripeptide argini ne-glycine-aspartic acid (RGD) as a surface ligand (RGD liposomes) wer e studied. The results suggest that the presence of the RGD ligand on the liposomes results in receptor-mediated mixing of lipid and aqueous contents of the liposomes and platelets. Mixing of the lipid and aque ous contents of RGD liposomes with platelets is approximately 4-9 time s and 3-4 times greater than that for unlabeled liposomes, respectivel y. Measurements of the cytoplasmic free Ca2+ concentration in platelet s, [Ca2+](i), show that the RGD liposomes have little effect on [Ca2+] (i). (C) 1996 Academic Press, Inc.