PSEUDOGENES FOR THE HUMAN URACIL-DNA GLYCOSYLASE ON CHROMOSOME-14 ANDCHROMOSOME-16

Two clones containing nonfunctional pseudogenes for the human uracil-D NA glycosylase gene have been isolated. The sequences of the two clone s that are homologous to the UNG cDNA span 670 and 580 bp, respectivel y. In the longest of these, a full length Sr type Alu sequence interru pts the homologous sequence. Chromosomal mapping locates the clones to chromosomes 16 and 14. Comparison of the pseudogene sequences to the cDNA sequence indicates that the pseudogenes diverged from the functio nal gene approximately 31 and 22 million years ago, which is before th e point in evolution when great apes and hominides separated. (C) 1996 Academic Press, Inc.