INTRALESIONAL NATURAL INTERFERON-ALPHA IN THE TREATMENT OF CROSTI LYMPHOMA (PRIMARY CUTANEOUS B FOLLICULAR CENTER-CELL LYMPHOMA) - REPORT OF 4 CASES

We describe four patients with Crosti's lymphoma, a non-Hodgkin's B-ce ll lymphoma of follicular centre origin, treated with intralesional na tural interferon alpha (IFN), In all patients the lesions cleared, Two patients had a clinical relapse but their lesions cleared after a sec ond course of therapy, Intralesional injections are thought to have a direct action on tumoral cells as well as a systemic effect, Given the high rate of relapse after radiotherapy (75%), natural IFN is a promi sing therapeutic alternative.