IMMUNOREACTIVE INHIBIN, MULLERIAN INHIBITORY SUBSTANCE, AND ACTIVIN AS BIOCHEMICAL MARKERS FOR JUVENILE GRANULOSA-CELL TUMORS

Ovarian juvenile granulosa cell tumors are a rare cause of sexual prec ocity. Clinical examination, serum estradiol levels, and pelvic imagin g studies have been used traditionally to detect such tumors. Immunoas says for mullerian inhibitory substance and inhibin have recently been noted to provide a more sensitive means of tumor detection in adults. We now describe two girls with this type of tumor in whom serum conce ntrations of inhibin and mullerian inhibitory substance were used as t umor markers.