CLINICAL-VALUE OF CA125, CA19-9, CEA, CA72-4, AND TPA IN BORDERLINE OVARIAN TUMOR

Five tumor markers were analyzed clinically in 101 patients with borde rline ovarian tumors who were treated by the Tokai Ovarian Tumor Study Group, an association comprising Nagoya University and its affiliated hospital, between January 1986 and December 1994. The positive rate o f CA125 was 68.2% in serous tumor and 51.9% in mucinous tumor. The pos itive rate of CA19-9 was 51.5% in serous tumor and 44.7% in mucinous t umor. The positive rates and mean serum levels of CA125 in serous and mucinous tumor by stage had rising tendencies with an increase in each stage. The mean serum levels of CA19-9 in serous and mucinous tumor b y stage had rising tendencies with an increase in each stage. CA125 an d CA19-9 were useful for screening of borderline ovarian tumors. The p ositive rates of CEA and TPA in mucinous tumor were 32.5 and 27.3%, re spectively, although none of the patients with serous tumor were posit ive in CEA and TPA. The positive rates and mean serum levels of CEA in mucinous tumor by stage had rising tendencies with an increase in eac h stage. The positive rate of CA72-4 was significantly lower than that of CA125 (P < 0.05). (C) 1996 Academic Press, Inc.