NEOADJUVANT CHEMOTHERAPY IN UTERINE PAPILLARY SEROUS CARCINOMA

Uterine papillary serous carcinoma (UPSC) is an aggressive variant of endometrial cancer that frequently imitates serous carcinoma of the ov ary in its clinical presentation and histologic appearance. Unlike the ovarian lesion, however, it is known to be particularly resistant to chemotherapy. A patient with a putative diagnosis of unresectable Stag e IV ovarian cancer was treated with three cycles of neoadjuvant chemo therapy containing paclitaxel and carboplatin. After a remarkable resp onse, interval cytoreductive surgery was performed. A primary endometr ial tumor with the pathologic features of UPSC was found. To our knowl edge, the use of paclitaxel-containing chemotherapy in UPSC has not be en reported. We suggest that this therapy might be useful in the treat ment of patients with advanced uterine papillary serous carcinoma, as well as in an adjuvant setting. (C) 1996 Academic Press, Inc.