EFFECT OF GONADOTROPIN-RELEASING-HORMONE ON ESTROGEN-RECEPTOR MESSENGER-RIBONUCLEIC-ACID LEVEL IN PERIFUSED PITUITARY-CELLS

Authors
DEMAY F TIFFOCHE C THIEULANT ML
Citation
F. Demay et al., EFFECT OF GONADOTROPIN-RELEASING-HORMONE ON ESTROGEN-RECEPTOR MESSENGER-RIBONUCLEIC-ACID LEVEL IN PERIFUSED PITUITARY-CELLS, Cellular and molecular neurobiology, 16(3), 1996, pp. 397-402
Citations number
7
Categorie Soggetti
Neurosciences,"Cell Biology",Biology
Journal title
Cellular and molecular neurobiology → ACNP
ISSN journal
02724340
Volume
16
Issue
3
Year of publication
1996
Pages
397 - 402
Database
ISI
SICI code
0272-4340(1996)16:3<397:EOGOEM>2.0.ZU;2-V
Abstract
1. We examined the potential effect of GnRH pulses on pituitary estrog en receptor mRNA level. 2. The treatment of perifused pituitary cell a ggregates with four hourly pubes of GnRH (10nM/1 min/h) resulted in a marked increase in the steady-state level of ER mRNA (25% vs unstimula ted control, n = 3). 3. No changes were observed for the LH beta mRNA. Data suggest, for the first time, that a cross-talk between the GnRH and nuclear ER may occur in the gonadotrope cells.