REACTION OF 4'-BENZYLOXY-2(4-PYRIDINYL)ACETOPHENONE WITH ETHYLMAGNESIUM CHLORIDE - UNUSUAL C-BENZYLATION AND IN-SITU REDUCTION BY BETA-HYDROGEN TRANSFER

Authors
HAROUTOUNIAN SA COULADOUROS EA
Citation
Sa. Haroutounian et Ea. Couladouros, REACTION OF 4'-BENZYLOXY-2(4-PYRIDINYL)ACETOPHENONE WITH ETHYLMAGNESIUM CHLORIDE - UNUSUAL C-BENZYLATION AND IN-SITU REDUCTION BY BETA-HYDROGEN TRANSFER, Liebigs Annalen, (7), 1996, pp. 1139-1141
Citations number
16
Categorie Soggetti
Chemistry
Journal title
Liebigs Annalen → ACNP
ISSN journal
09473440
Issue
7
Year of publication
1996
Pages
1139 - 1141
Database
ISI
SICI code
0947-3440(1996):7<1139:RO4WE>2.0.ZU;2-W
Abstract
In solution, 4'-benzyloxy-2-(4-pyridinyl)acetophenone (I) mainly exist s as enol 4 which does not undergo typical Grignard addition reactions . Treatment with an excess of ethyl-magnesium chloride, however, initi ates an unusual sequence of transformations leading to formation of th e C-benzylated compounds 2 and 3.