A rotary blood pump inherently provides only one noninvasive ''observa
ble'' parameter (motor current) and allows for only one ''controllable
'' parameter (pump speed). To maintain the systemic circulation proper
ly, the pump speed must be controlled to sustain appropriate outlet fl
ows and perfusion pressure while preventing pulmonary damage caused by
extremes in preload. Steady-state data were collected at repeated int
ervals during chronic trials of the Nimbus AxiPump (Nimbus, Inc., Ranc
ho Cordova, California, U.S.A.) in sheep (n = 7) and calves (n = 12).
For each data set, the pump speed was increased at increments of 500 r
pm until left ventricular and left atrial emptying was observed by lef
t atrial pressure diminishing to zero. The effect of decreasing preloa
d was evaluated perioperatively by inferior vena cava occlusion at a c
onstant pump speed. Fourier analysis established a relationship betwee
n changes in the pump preload and the power spectra of the pump curren
t waveform. Based on these results, a control method was devised to av
oid ventricular collapse and maintain the preload within a physiologic
range. The objective of this controller is the minimization of the se
cond and third harmonic of the periodic current waveform. This method
is intended to provide a noninvasive regulation of the pump by elimina
ting the need for extraneous transducers.