FLUCTUATIONS OF THE HEMODYNAMIC DERIVATIVES DURING LEFT-VENTRICULAR ASSISTANCE USING OSCILLATED BLOOD-FLOW

To analyze the autonomic nervous system during left heart bypass with a vibrating flow pump (VFP), fluctuations in hemodynamic derivatives w ere evaluated by the spectral analysis method using fast fourier trans form methodology. After the left pleural cavity was opened through the fourth intercostal space under general anesthesia, a VFP was implante d as the left heart bypass device in chronic animal experiments using 3 healthy adult goats. Hemodynamic parameters with and without VFP ass istance were recorded on magnetic tape in awake animals and were analy zed by computer through an analog to digital convertor. Power spectral analysis was performed on a beat-to-beat basis for the evaluation of the fluctuations. During left heart bypass with the VFP, Mayer wave fl uctuations were decreased significantly although respiratory waves wer e not changed significantly, These results suggest that sympathetic ne rvous system modulation was changed under the influences of the left h eart bypass with VFP, By using this analysis methodology, truly physio logic ventricular assistance may be achieved.