M. Yoshikai et al., CLINICAL USE OF CENTRIFUGAL PUMPS AND THE ROLLER-PUMP IN OPEN-HEART-SURGERY - A COMPARATIVE-EVALUATION, Artificial organs, 20(6), 1996, pp. 704-706
Centrifugal pumps have been used widely as the main pump in open heart
surgery to reduce damage to blood elements and to reduce the activati
on of the coagulation system. The purpose of this study was the evalua
tion and comparison of the effects Of two types of centrifugal pumps a
nd of one type of roller pump on blood elements, the coagulation syste
m, complements,:and immunoglobulins. Two types of centrifugal pumps (L
ifestream; St. Jude Medical, Chelmsford, Massachusetts; and BP-80; Med
tronic, BioMedicus, Inc., Eden Prairie, Minnesota, U.S.A.) and one rol
ler pump (Mera Co.) were used separately as the main pump for cardiopu
lmonary bypass (CPB) in 29 patients. Platelet counts, lactate dehydrog
enase, antithrombin III, thrombin-antithrombin complex (TAT), compleme
nts (C3, C4, and CH50) and immunoglobulins G, A, and M values were mea
sured before and after CPB and compared. Values, except those for TAT,
showed no significant difference among the three groups. The TAT valu
es increased less in each of the centrifugal pump groups than in the r
oller pump group. This finding suggests that thrombin synthesis might
be suppressed by the use of a centrifugal pump.