FORCED OVER-EXPRESSION OF THE MYELOID ZINC-FINGER GENE MZF-1 INHIBITSAPOPTOSIS AND PROMOTES ONCOGENESIS IN INTERLEUKIN-3-DEPENDENT FDCP.1 CELLS

Authors
HROMAS R BOSWELL S SHEN RN BURGESS G DAVIDSON A CORNETTA K SUTTON J ROBERTSON K
Citation
R. Hromas et al., FORCED OVER-EXPRESSION OF THE MYELOID ZINC-FINGER GENE MZF-1 INHIBITSAPOPTOSIS AND PROMOTES ONCOGENESIS IN INTERLEUKIN-3-DEPENDENT FDCP.1 CELLS, Leukemia, 10(6), 1996, pp. 1049-1050
Citations number
10
Categorie Soggetti
Hematology,Oncology
Journal title
Leukemia → ACNP
ISSN journal
08876924
Volume
10
Issue
6
Year of publication
1996
Pages
1049 - 1050
Database
ISI
SICI code
0887-6924(1996)10:6<1049:FOOTMZ>2.0.ZU;2-8
Abstract
The myeloid zinc finger protein MZF-1 is important in hematopoiesis. P revious studies have found that reducing expression of MZF-1 inhibited G-CSF-driven human marrow colony formation assays. In this study we f ound that retrovirally overexpressing MZF-1 in IL-3-dependent FDCP.1 c ells inhibited their apoptosis when IL-3 was withdrawn. The MZF-1-tran sduced FDCP.1 cells also formed tumors when injected into congenic mic e, whereas control FDCP.1 cells did not.