POTENTIAL ANTITUMOR AGENTS .24. SYNTHESIS AND PHARMACOLOGICAL BEHAVIOR OF IMIDAZO[2,1-B]THIAZOLE GUANYLHYDRAZONES BEARING AT LEAST ONE CHLORINE

In connection with a previous research dealing with the antitumor acti vity of imidazo[2,1-b]-thiazole guanylhydrazones, this paper reports t he synthesis of new derivatives which were tested for antitumor and po sitive inotropic activity. In most cases the cytotoxic data from the i n vitro experiments (HeLa) were in agreement with the antitumor data i n vivo (Ehrlich). The active compounds bear a phenyl ring at the 6 pos ition. On the other hand, the most active cardiotonic agents were devo id of the phenyl ring.