IMAGING CALCIUM DYNAMICS IN DENDRITIC SPINES

Authors
DENK W YUSTE R SVOBODA K TANK DW
Citation
W. Denk et al., IMAGING CALCIUM DYNAMICS IN DENDRITIC SPINES, Current opinion in neurobiology, 6(3), 1996, pp. 372-378
Citations number
63
Categorie Soggetti
Neurosciences
Journal title
Current opinion in neurobiology → ACNP
ISSN journal
09594388
Volume
6
Issue
3
Year of publication
1996
Pages
372 - 378
Database
ISI
SICI code
0959-4388(1996)6:3<372:ICDIDS>2.0.ZU;2-O
Abstract
Recent advances in optical imaging technology have enabled the measure ment of Ca2+ dynamics in individual synaptic spines with high time res olution. Results from work using this new technology have confirmed th e view that individual synaptic spines can act as functional chemical compartments with independent dynamics of second-messenger concentrati on. In particular, the ability of Ca2+ to directly mediate Hebbian coi ncidence detection has been confirmed.