Js. Lee et al., FINE-NEEDLE ASPIRATION CYTOLOGY OF ANAPLASTIC CARCINOMA WITH OSTEOCLAST-LIKE GIANT-CELLS OF THE THYROID - A CASE-REPORT, Acta cytologica, 40(6), 1996, pp. 1309-1312
BACKGROUND: Multinucleated giant cells of osteoclastlike appearance ar
e seen in some anaplastic carcinomas, but only three cases in which th
e diagnosis was made by aspiration cytology are reported in the intern
ational medical literature. CASE: A 66-year-old female presented with
a history of a palpable neck mass. The diagnosis of fine needle aspira
tion cytology was anaplastic thyroid carcinoma with osteoclastlike gia
nt cells. Immunohistochemical staining and DNA ploidy analysis were do
ne. CONCLUSION: Osteoclastlike giant cells have an origin different fr
om that of the anaplastic component. DNA aneuploidy was noted in our c
ase.