THE AUTOIMMUNE BASIS OF ADRENOCORTICAL DESTRUCTION IN ADDISONS-DISEASE

Authors
WINQVIST O SODERBERGH A KAMPE O
Citation
O. Winqvist et al., THE AUTOIMMUNE BASIS OF ADRENOCORTICAL DESTRUCTION IN ADDISONS-DISEASE, Molecular medicine today, 2(7), 1996, pp. 282-289
Citations number
41
Categorie Soggetti
Medicine, Research & Experimental",Biology,"Cell Biology
Journal title
Molecular medicine today → ACNP
ISSN journal
13574310
Volume
2
Issue
7
Year of publication
1996
Pages
282 - 289
Database
ISI
SICI code
1357-4310(1996)2:7<282:TABOAD>2.0.ZU;2-B
Abstract
Addison's disease is mainly caused by autoimmune destruction of the st eroid-producing cells in the adrenal glands. Key enzymes in steroid bi osynthesis have been if implicated as the major targets of autoantibod ies in this disease. The study of B-cell-dependent autoimmune response s reveals two distinguishable forms of Addison's disease. This should permit very accurate diagnosis of the disease and increase future pros pects of disease prevention.