VENTRICULAR PREMATURE BEAT-DRIVEN INTERMITTENT RESTORATION OF CORONARY BLOOD-FLOW REDUCES THE INCIDENCE OF REPERFUSION-INDUCED VENTRICULAR-FIBRILLATION IN A CAT MODEL OF REGIONAL ISCHEMIA
Hs. Na et al., VENTRICULAR PREMATURE BEAT-DRIVEN INTERMITTENT RESTORATION OF CORONARY BLOOD-FLOW REDUCES THE INCIDENCE OF REPERFUSION-INDUCED VENTRICULAR-FIBRILLATION IN A CAT MODEL OF REGIONAL ISCHEMIA, The American heart journal, 132(1), 1996, pp. 78-83
With a cat model of regional cardiac ischemia, we examined whether the
incidence of reperfusion-induced ventricular fibrillation (VF) could
be reduced by ventricular premature beat (VPB)-driven intermittent rep
erfusion. In addition, we assessed whether the effect of the intermitt
ent reperfusion was comparable with that df ischemic preconditioning i
n suppressing the VF. Of 15 cats subjected to uninterrupted reperfusio
n after 20-minute occlusion of the left anterior descending coronary a
rtery, 13 (85.7%) had VF, whereas only 1 (7.1%) of 14 cats subjected t
o the VPB-driven intermittent reperfusion had VF. This incidence of Vf
was significantly lower than that of the animal group subjected to un
interrupted reperfusion. However, it was not statistically different f
rom that (3 of 15) of the group subjected to a 10-minute episode of th
e coronary artery occlusion before the 20-minute occlusion (i.e., ''is
chemic preconditioning''). Our results suggest that the VPB-driven int
ermittent reperfusion (i.e., ''postconditioning'') is very effective i
n preventing reperfusion-induced VF and as good as, if not better than
, ischemic preconditioning.