GROWTH-HORMONE MODULATES IL-ALPHA AND 1FN-GAMMA RELEASE BY MURINE SPLENOCYTES ACTIVATED BY LPS OR PORINS OF SALMONELLA-TYPHIMURIUM

Authors
SOMMESE L DONNARUMMA G DELERO GC MARCATILI A VITIELLO M
Citation
L. Sommese et al., GROWTH-HORMONE MODULATES IL-ALPHA AND 1FN-GAMMA RELEASE BY MURINE SPLENOCYTES ACTIVATED BY LPS OR PORINS OF SALMONELLA-TYPHIMURIUM, Journal of Medical Microbiology, 45(1), 1996, pp. 40-47
Citations number
36
Categorie Soggetti
Microbiology
Journal title
Journal of Medical Microbiology → ACNP
ISSN journal
00222615
Volume
45
Issue
1
Year of publication
1996
Pages
40 - 47
Database
ISI
SICI code
0022-2615(1996)45:1<40:GMIA1R>2.0.ZU;2-O
Abstract
The effect of growth hormone (GH) on the release of IL-1 alpha and IFN -gamma from murine splenocytes was investigated. Their release from sp lenocytes activated by Salmonella enterica serovar Typhimurium lipopol ysaccharide (LPS) 0.5 mu g/ml was increased by c. 65% in the presence of GH 100 pg/ml. With splenocytes activated by S. Typhimurium porins 5 mu g/ml, GH increased the production of both IL-1 alpha and IFN-gamma by c. 56%. Polymyxin treatment abolished the cytokine-releasing activ ity of LPS but had no effect on the activity of the porin preparation.