LOSS OF AN X-CHROMOSOME IN AGGRESSIVE ANGIOMYXOMA OF FEMALE SOFT PARTS - A CASE-REPORT

Authors
KENNYMOYNIHAN MB HAGEN J RICHMAN B MCINTOSH DG BRIDGE JA
Citation
Mb. Kennymoynihan et al., LOSS OF AN X-CHROMOSOME IN AGGRESSIVE ANGIOMYXOMA OF FEMALE SOFT PARTS - A CASE-REPORT, Cancer genetics and cytogenetics, 89(1), 1996, pp. 61-64
Citations number
20
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
89
Issue
1
Year of publication
1996
Pages
61 - 64
Database
ISI
SICI code
0165-4608(1996)89:1<61:LOAXIA>2.0.ZU;2-B
Abstract
Cytogenetic analysis of an aggressive angiomyxoma of the vulvar region of a 16-year-old female revealed loss of one X chromosome (45,X, -X) in eight of 20 metaphase cells analyzed. Fluorescence in situ hybridiz ation (FISH) performed on disaggregated cells from paraffin embedded l esional tissue confirmed loss of an X chromosome in 31% of cells. Cyto genetic analysis performed on peripheral blood showed a normal chromos omal complement (46,XX). Thus, loss of one X chromosome appears to be confined to the neoplasm. This anomaly has not been previously describ ed in aggressive angiomyxoma.