RENAL-CELL CARCINOMA IN AN END-STAGE KIDNEY OF A PATIENT WITH A FUNCTIONAL TRANSPLANT - CYTOGENETIC AND MOLECULAR-GENETIC FINDINGS

Renal cell carcinomas (RCCs) occur at an increased rate and at a young er age in patients with end-stage renal disease (ESRD) than in the gen eral population. A papillary RCC from a patient with ESRD treated by h emodialysis and then by renal transplantation was karyotyped and showe d a 55,XY,+2,+4,+7,+10,+12,+16,+17,+17,+20 mainline. No loss of gene s equences in the short arm of chromosome 3 was identified by chromosoma l or molecular genetic analysis. Together with one prior report of a c ytogenetic study of a RCC in an end-stage kidney, the findings indicat e that papillary RCCs that arise in ESRD patients have genetic changes that are similar to those found in sporadic tumors. The increased fre quency of rumors and the younger age of the patients may be due to an increased rate at which abnormal mitoses occur in diseased renal tissu es.