DOXEPIN ION-SELECTIVE MEMBRANE-ELECTRODE, PREPARATION AND USE IN PHARMACEUTICAL ANALYSIS

obtained ion-pair complex of doxepin-tetraphenylborate was used as an electroactive material with poti(vinyl chloride) membrane. The electro de exhibits near Nernstian response for doxepin. The electrode based o n doxepin-tetraphenylborate as an ion exchanger and 2-nitrophenyloctyl ether as plasticiser provides a rapid and sensitive method for doxepi n determination. The determination of doxepin hydrochloride in a subst ance and in pharmaceutical preparations by potentiometric titration ga ve an average recovery of 100.3% and relative standard deviation of 1. 1%.