THE EFFECT OF SOME 2-SUBSTITUTED QUINOLINES ISOLATED FROM GALIPEA-LONGIFLORA ON PLASMODIUM-VINCKEI-PETTERI INFECTED MICE

Authors
GANTIER JC FOURNET A MUNOS MH HOCQUEMILLER R
Citation
Jc. Gantier et al., THE EFFECT OF SOME 2-SUBSTITUTED QUINOLINES ISOLATED FROM GALIPEA-LONGIFLORA ON PLASMODIUM-VINCKEI-PETTERI INFECTED MICE, Planta medica, 62(3), 1996, pp. 285-286
Citations number
6
Categorie Soggetti
Pharmacology & Pharmacy","Plant Sciences
Journal title
Planta medica → ACNP
ISSN journal
00320943
Volume
62
Issue
3
Year of publication
1996
Pages
285 - 286
Database
ISI
SICI code
0032-0943(1996)62:3<285:TEOS2Q>2.0.ZU;2-Y
Abstract
We have evaluated the in vivo antiplasmodial activity of six 2-substit uted quinolines and a total alkaloidal extract of Galipea longiflora. BALB/c mice infected with Plasmodium vinckei petteri were treated oral ly at single dose of 50 mg/kg with quinolines or extract. Contrary to the previous results obtained with the Leishmania murine infection, 2- n-pentylquinoline showed activity against P. vinckei petteri. This res ult seems to confirm the antimalarial efficacy of infused stem bark of G. longiflora.