DOSE-DEPENDENT ELIMINATION KINETICS FOR MERCURY IN URINE - OBSERVATIONS IN SUBJECTS WITH BRIEF BUT HIGH-LEVEL EXPOSURE

Objectives-To study the elimination kinetics for mercury in urine (U-H E) after brief but high-level exposure. Methods-U-Hg was examined in I I workers after 2-10 days of exposure to inorganic Hg and after sympto ms and signs of Hg intoxication had appeared. Initial U-Hg excretion v aried between 60 and 2360 mu g/g creatinine. The subjects were followe d up for 1-11 months. In each subject, one- and two-compartment models were fitted to the U-HE values, assuming an exponential decrease, by weighted non-linear least-squares regression (weight = 1/U-Hg). Result s-The data indicated two elimination phases in subjects with initial U -Hg above 600 mu g/g. In the two-compartment models, there was a fast phase with a half-time of 2-16 days, and a slow phase with a halftime of more than a month. The fast phase contributed 70-90% to the sum of the Y intercepts. Conclusions-The kinetics of U-Hg excretion after ces sation of exposure seems to be dose-dependent and, at least in certain cases, to have two phases, The explanation for the fast phase may be that the capacity of certain binding sites in the kidney was exceeded.