Recurrent fetal loss and pregnancy complications, especially severe ea
rly-onset preeclampsia, are frequently associated with anti-phospholip
id antibodies. We report a case of postpartum cardiac involvement lead
ing to dilated cardiomyopathy in a woman with a persistent positivity
for anti-cardiolipin and anti-nuclear antibodies. Her clinical and obs
tetric record reported two previous fetal losses but no other signs ch
aracteristic of the anti-phospholipid syndrome or diagnostic for a sys
temic lupus erythematosus. Post-partum cardiomyopathy might be another
cardiac presentation of the anti-phospholipid syndrome, in addition t
o the well known valvular involvement. In patients with persistent pos
itivities for anti-phospholipid antibodies, a prompt identification of
such a complication in the postpartum period should be taken into acc
ount by physicians. Adequate cardiologic treatment associated with ant
iaggregant and steroid therapy might be useful to prevent further comp
lications in these patients.